Case Closed's Science Information

1 . Person dies , the body 's metabolism will be stopped . Although the room temperature rose she will not sweat .

2 . That burned corpse , his muscles will coagulate and shrink due to the searing temperatures .

3 . Operation bone marrow to treat leukemia may alter the patient's blood group be the same with donors

4 . Stimulation of contact lenses that are not good for itchy eyes due to hay fever .

5 . People who wear a pacemaker to help his heart work will avoid phone that emits radio waves

6 . People who sneeze acute back pain by releasing the breath of the mouth for fear of burdening the body

7 . Very hard blow to the head can drop a contact lens in the eye that is being used

8 . Never shave razor while bathing because the machine that turns on when it fell , would electrocute

9 . It takes at least half an hour so that the blood can dry

10 . Ran live with Kogoro when they split because Japanese law does require that the child lived with father

11 . People who wear glasses myopic eyes with minus will not fit squint to clarify vision.

12 . Heparin or anti thickening blood can be make half frozen and can be borrowed.

13 . Cats do not have the enzyme to break down lactose .

14 . How to detect lies through the eyeball : the longer he blinks, he lied .

15 . Luminol fluid blood which is very sensitive to even slight.

16 . Nails are part of the human body number 2 who could be the loudest and gear cutting tools after

17 . Potassium cyanide can kill only with a dose of 5 mg alone .

18 . After drinking alcohol , org will become dehydrated and dry their throats because the decomposition of alcohol.

19 . Data credibility needed to convince the court officer that a warrant can be made .

20 . Veterinarian to make sure what the dog is sick or not through state and odor in his ears .

21 . Safety on the gun type tokalev be installed when the trigger on tap slowly and stopped in the middle

22 . When seseorg not honoring agreements related to issues of civil law , then the sanctions must surrender all his property

23 . Habu sea snakes never intentionally bite humans because basically they will be docile snake

24 . The corpse could not leave fingerprints because the sweat was stopped after 30 minutes of time of death

25 . According to research Ai , APTX 4869 could increase cell multiplication as activating teromeaze

26 . Perforated lung who have stabbed the victim suffered a 15 -minute lead with an acute respiratory distress conditions

27 . Chalk has issued a heat when absorbing properties of water

28 . hoarding corpses in the ground can be faked death corpse because its decay time is relatively long

29 . Sudden death due to vigorous exercise can accelerate stiffness corpse . It could also cause death stand

30 . Lime can be used to accelerate the decomposition of a body

31 . Helping victims who were exposed to the neurotoxin give artificial respiration with the routine every 10 seconds

32 . When seseorg dead hanging himself , which is impossible when there is blood flowing from his mouth unless there is a specific injury

33 . When the lever mercury ball rolling and touching lines by shock , then the time bomb will explode

34 . Salt can be used to harden the snow and usually used to make ski runs

35 . Neutralize potassium cyanide can use bleach , but not 100 % gone toxic

36 . Cow's milk that herbivores have a nutritional value of milk and different with carnivorous cat

37 . If the blood sugar -lowering drugs taken by a guy who is healthy, then the person get blood sugar will drop dramatically & bs cause death

38 . Org who fainted with shock restored sun compress the head , chest and armpits and then sleep in the shade

39 . Torigabuto herbs can also be used if the poison was taken . Many grow in the mountains and very sweet flower shape

40 . Aconitin ( paralyzing nerve toxin ) captured dr torigabuto leaves and roots have a 2 milligram dose of death

41 . Acute bleeding brain membrane that is characterized with right hand paralyzed and bleeding in the head

42 . Isoproterenol is a drug that can cause fainting org , tp jg can be used as an asthma medication with dose when the true

43 . Tetrodoxin toxins ( TTX ) dr globe fish when inserted through the mouth is bs rescued , if tp does not pass the blood

44 . Clean the wound with tea that contains tannin is the best way to save a sea snake bite victim

45 . First aid sodium hydroxide poisoning victims who were cleaning the victim's mouth with a protein drink

46 . How to cope with the transfer fraud :
a. Do not panic alone .
b . Do not make hasty decisions .
c . Tell anyone. Because people will solve the problem objectively based on the words and explanations of others. Thus, you can understand the problem with a head cold .

For a closer view, read the Indonesian Language View. Sorry if the English is not that good :(

1. Orang meninggal, metabolisme tubuhnya akan terhenti. Walaupun suhu ruangan naik dia takkan berkeringat.

2. Mayat yg terbakar, otot tubuhnya akan menggumpal & menyusut akibat suhu yg panas.

3. Operasi sumsum tulang untuk mengobati leukemia dapat merubah golongan darah penderita menjadi sama dgn pendonor

4. Rangsangan lensa kontak tidak baik untuk mata yg gatal akibat alergi serbuk bunga.

5. Orang yg memakai alat pacu jantung untuk membantu kerja jantungnya akan menghindari ponsel yg memancarkan gelombang radio

6. Orang yg sakit pinggang akut bersin dengan cara mengeluarkan napas dari mulut karena takut membebani tubuh

7. Hantaman sangat keras di kepala dapat menjatuhkan lensa kontak yg sedang dipakai di mata

8. Jangan pernah bercukur sambil berendam karena mesin cukur yg menyala bila tercebur, akan menyetrum

9. Setidaknya butuh waktu setengah jam agar darah dapat mengering

10. Ran tinggal bersama Kogoro saat mereka pisah karena hukum Jepang memang mengharuskan anak tinggal dengan ayah

11. Orang bermata rabun yg memakai kacamata dgn minus tidak pas akan menyipitkan mata untuk memperjelas penglihatan

12. Heparin atau obat anti pengental dpt membuat darah jd setengah beku & dapat dibawa2

13. Kucing tidak punya enzim untuk mengurai laktosa.

14. Cara mendeteksi kebohongan lewat bola mata : semakin lama ia berkedip, berarti ia berbohong.

15. Cairan luminol sangat sensitif terhadap darah yg sedikit sekalipun

16. Kuku adalah bagian tubuh manusia nomor 2 yg paling keras dan bisa jadi alat potong setelah gigi

17. Kalium sianida bisa membunuh hanya dengan dosis 5 mg saja.

18. Setelah minum alkohol, org akan mengalami dehidrasi & tenggorokan mereka kering karna dekomposisi alkohol.

19. Data kredibilitas diperlukan untuk meyakinkan petugas pengadilan agar dapat dibuat surat penangkapan.

20. Dokter hewan memastikan apa anjing itu sakit atau tidak melalui keadaan dan bau di dalam telinganya.

21. Safety pada pistol jenis tokalev akan terpasang bila pemicu di tekan perlahan lalu berhenti di tengah tengah

22. Bila seseorg tidak menepati perjanjian hukum terkait masalah perdata, maka sanksinya harus menyerahkan seluruh hartanya

23. Ular laut habu tidak pernah sengaja menggigit manusia karena pada dasarnya ular tsb jinak

24. Mayat tidak bisa meninggalkan sidik jari karena keringat sudah berhenti setelah 30 menit waktu kematian

25. Menurut penelitian Ai, APTX 4869 dapat meningkatkan daya multiplikasi sel karena mengaktifkan teromeaze

26. Paru paru yg berlubang karena ditusuk mengakibatkan korban menderita 15 menit dgn kondisi sesak nafas akut

27. Kapur memiliki sifat mengeluarkan panas jika menyerap air

28. menimbun mayat di dalam tanah dapat memalsukan waktu kematian mayat karena pembusukannya relatif lama

29. Kematian mendadak akibat olahraga keras dapat mempercepat kekakuan mayat. Bisa juga menyebabkan mati berdiri

30. Kapur dapat digunakan untuk mempercepat pembusukan mayat

31. Menolong korban yg terkena racun syaraf adalah dgn memberi nafas buatan rutin tiap 10 detik

32. Bila seseorg mati gantung diri, mustahil bila terdapat darah yg mengalir dari mulutnya kecuali ada luka tertentu

33. Bila bola dalam tuas air raksa bergulir dan menyentuh garis akibat guncangan, maka bom waktu akan meledak

34. Garam dapat dipakai untuk mengeraskan salju dan biasa dipakai untuk membuat lintasan ski

35. Menetralisir kalium sianida dapat menggunakan pemutih, tapi tidak 100% hilang racunnya

36. Susu sapi yg herbivora memiliki nilai gizi yg beda dgn susu kucing yg karnivora

37. Jika obat penurun gula darah diminum oleh org yg sehat, maka gula darah org tsb akan turun drastis & bs menyebabkan kematian

38. Org yg pingsan terkena sengatan matahari dipulihkan dgn mengompres kepala, dada & ketiak lalu tidur di tempat teduh

39. Torigabuto juga bisa dijadikan jamu jika racunnya diambil. Banyak tumbuh di gunung & bentuk bunganya sangat manis

40. Aconitin (racun pelumpuh syaraf) yg diambil dr daun & akar torigabuto memiliki dosis kematian 2 miligram

41. Pendarahan selaput otak akut ditandai dgn tangan kanan yg lumpuh & pendarahan hebat di kepala

42. Isoproterenol adalah obat yg dapat menyebabkan org pingsan, tp jg bisa dipakai sbg obat asma bila dgn takaran yg benar

43. Racun Tetrodoxin (TTX) dr ikan gembung bila dimasukkan lewat mulut masih bs diselamatkan, tp tidak bila lewat darah

44. Membersihkan luka dgn teh yg mengandung tanin adalah cara terbaik menyelamatkan korban gigitan ular laut

45. Pertolongan pertama korban yg keracunan sodium hidroksida adalah membersihkan mulut korban dgn minuman berprotein

46. Cara mengatasi penipuan transfer :
a. Jangan panik sendirian.
b. Jangan membuat keputusan tergesa-gesa.
c. Ceritakanlah pada siapa saja. Karena orang akan menyelesaikan masalah secara objektif berdasarkan kata-kata dan penjelasan orang lain. Sehingga, Anda bisa memahami masalah dengan kepala dingin.

APTX 4869

APTX 4869 (四八六九 Yon-Hachi-Roku-Kyuu), nicknamed "Prototype Detective" by members of the Black Organization, is a fictional toxin and derivative of an experimental formula of unknown purpose developed by Shiho Miyano, which is used by the Black Organization as an untraceable, lethal poison. Right now, there is aprototype antidote for it made by Shiho.

Description

APTX is an abbreviation of "Apoptoxin," and, as the name implies, it involves the activation of apoptosis: the mechanism by which cells kill themselves. APTX contains ingredients which have other functions as well. It contains a component which activates telomerase: an enzyme which lengthens the caps at the end of DNA whose length limits the number of times a cell can divide. In practice, most of the time APTX 4869 works as a lethal poison. Gin says it can't be detected when used, possibly indicating it leaves few traces that forensic examination could uncover. However, as said by Ai Haibara, a rare side effect can in fact de-age victims. She said in Episode 129, that everything besides organs, body hair, personality, and memories are reverted back to a state of ages 7-10 years old. Shinichi, the series' protagonist, was forced by Gin and Vodka to take the poison with the intention of killing him silently due to the police being around in Episode 1; later Shiho Miyano, was set to be executed for being a possible loose end after Gin and Vodka killed her sister Akemi. She was set to be executed, but to escape she took her own poison intending to commit suicide, however her body, like Shinichi's, was reverted back to childhood state.

Name Origin

APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-Ro-Ku", which translates into Sherlock. Adding to the pun, the password for the APTX data is "Shellingford"^[1], an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock". The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective",implying APTX 4869 is not finished yet.

Antidote

Gin poisons Shinichi.

Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The main ingredient for this reversal is a component found in baijiu, which Haibara has already incorporated in a prototype antidote for the APTX.

It is notable that in the instances where Shinichi or Shiho were successfully changed back, the recipient was suffering from a common cold while the component was ingested, indicating that the immune system somehow has to be taxed for the antidote to work. The only apparent canon exception was Shinichi's reversion in the London arc. While not canon, Crossroad in the Ancient Capital uses this idea as Conan is given a pill to give him the symptoms of a cold, while drinking baijiu.

Conan and Haibara briefly reverted to their true age while having rum cake (thought to contain among other things baijiu) in the live action drama Shinichi Kudo Returns! Confrontation with the Black Organization.

Speculation

Original intent

At first, it was revealed by Gin that the APTX 4869 was a poison to kill people who know too much about the Black Organization. He used Shinichi as a guinea pig. Shiho Miyano said that she didn't intend to create a poison, which suggests that APTX 4869 was originally developed with a different goal in mind. It probably was just a useful side effect that the current prototype kills while leaving no trace in the victim’s body, and was thus employed as a poison - a usage which Haibara detests.Additionally, APTX 4869 is nicknamed the "incomplete detective" by the Black Organization, which means its true purpose has not yet been achieved.

Immortality/anti-aging

One possibility is that the goal of the APTX 4869 is to develop a therapy which will cause immortality, stall or reverse the effects of aging, or extend a human's lifespan. The de-aging effect that occurred when Shinichi and Haibara took APTX 4869 probably indicates the main intent of the drug's development. After Pisco saw Haibara shrink back to her child form, he commented that he was impressed she had developed the drug to that point, implying that deaging is in the right direction. Supporting this is Haibara’s line, "Kudo-kun? You would probably never even dream that you are already part of a project the Black Organization has been working on already for half a century." APTX 4869 is the only known intersection between Shinichi and the Black Organization; meaning that Shinichi's de-aging made him relevant to the Black Organization's project.

According to Haibara’s description about APTX 4869, APTX 4869 activates telomerase, an enzyme which can increase the number of times a cell can divide, and therefore affect a cell's lifespan and “reproductive potential”. The goal of this might be to revert all non-neural cells to a "youthful", high reproductive potential state. Vermouth's unnatural youth is another indicator that the Black Organization may be involved in research towards extending lifespan, halting aging, or rejuvenating the body.

The goal of the antagonists in Magic Kaito is pursuing immortality, via the Pandora Gem, but it is unclear whether if the organization in Magic Kaito is the same one as the Black Organization.

Raising the dead

The original purpose of APTX 4869 might be to raise the dead. Once when Conan asked Haibara directly what APTX 4869 was meant to do she replied, "It's a nostrum to raise the dead. I wonder if that answer is satisfactory?" The context of the comment, however, makes it unclear if she was merely bluffing to provoke Conan into revealing that he had been looking into the Black Organization behind her back, rather than making a serious statement of the purpose of the drug.

"Silver Bullet" and "APTX 4869" are two names for the same project

In a flashback, Shiho recalls the end of the recorded message left by her mother which revealed Elena had been working on "a truly terrifying drug" the Miyano parents called the Silver Bullet. It is unclear whether Silver Bullet is the Miyano parents' personal nickname for what is currently called APTX 4869, or if it was a closely related project they developed in parallel. Whatever the case, Silver Bullet and APTX 4869 are probably closely linked if not the same in-development drug. Haibara took over her parents' research after they died, with the APTX project named specifically. After watching Haibara shrink, Pisco, who knew about the project the Miyanos worked on, commented that Shiho's parents would be proud of the progress Shiho had made on the drug.

 In addition, Haibara had earlier referred to APTX 4869 as a dream-like drug. the same expression Elena's labmates used to describe Silver Bullet. During her recollection of the tapes, Haibara was holding and considering the antidote to APTX 4869. She then regrets that she didn't understand the drug was something that should have never been made, strongly implying she worked on the same drug as well. Lastly, Vermouth, who was in the Organization long enough to have heard the Miyanos use the name "Silver Bullet", may have given Conan the same nickname in reference to his deaged state caused by the drug.